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[20] [21] This rapid breakdown necessitated the development of modified GLP-1 receptor agonists that resist enzymatic degradation, allowing for once-daily or even once-weekly administration
Its active ingredient, tirzepatide, is a dual-agonist. It mimics not only GLP-1 but also another gut hormone called glucose-dependent insulinotropic polypeptide (GIP)
It claimed 'GLP-1s for diabetes could be sold at a profit for just US $0.89 per month, compared to the price of $95 per month charged in Brazil, $115 per month charged in South Africa, $230 charged in Latvia and $353 charged in the US, which is a 39,562% markup over what the estimated generic price could be.' Christa Cepuch, Pharmacist Coordinator at MSF's Access Campaign, argues 'These new drugs are an absolute game changer for people living with diabetes, but are being kept out of the hands of hundreds of millions of people in low- and middle-income countries who need them' (Barber, Gotham, Bygrave
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