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However, trends showed a dose-dependent increase in gastrointestinal disorder risk (RR ranging from 1.52 to 2.70) and greater cardiovascular protection at higher doses (RR = 0.76)
Exclusion criteria included (a) clinical studies that had menopause hormone therapy as a treatment, (b) case reports, (c) in vitro studies or (d) animal studies, and (e) duplicate articles or off-topic articles
Gunal, A
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