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The primary molecular target of the TB-500 fragment is monomeric G-actin: thymosin beta-4 is the most important intracellular G-actin-sequestering peptide and buffers the equilibrium between G- and F-actin, by which it regulates cytoskeletal dynamics, cell migration, angiogenesis and wound repair
doi: 10.1016/j.atherosclerosis.2015.12.022 110 van DiepenJABerbeJFHavekesLMRensenPC
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