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172 Natural compounds such as curcumin, quercetin, and salvianolic acid B have also demonstrated transporter-inhibitory properties with relatively low toxicity, although issues with solubility and bioavailability have limited their clinical utility and prompted formulation optimization

Hormesis: from mainstream to therapy

In this regard, we include three clinical studies published from 2021 to 2023 based on the inclusion criteria that examined oral curcumin supplementation, primarily in women who were 30 to over 60 years of age (Table 2)