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Others maintain patients on continuous therapy for years without apparent loss of efficacy
Krller-Schn S et al (2014) Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen speciesstudies in white blood cells and in animal models
It does not alter losartan's plasma half-life (approximately 2 hours for losartan, 6 to 9 hours for its active metabolite E-3174), its protein binding (~99%), or its renal clearance
(6) Similarly, Gobburu et al
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