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Nanoparticles were diluted in phenol red-free DMEM/HAMs F-12 medium (Gibco, Life Technologies, Carlsbad, CA, USA) supplemented with 5% FBS at a final concentration of 100 g/ml and added to the donor compartment (0.2 ml)

One hundred units equals 1.0mL

Whats remarkable about this comparison is that both naltrexone and topiramate have been shown to be effective in treating alcohol use disorder and are commonly prescribed for this purpose, in addition to their uses for obesity

Endothelial dysfunction and breakdown of the bloodbrain barrier are now recognized as early contributors to cognitive decline, often preceding overt neuronal loss