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The IMMU-132-01 study included a single-arm expansion cohort of 54 patients with previously treated NSCLC achieving an ORR of 16.7%, median DoR of 6 months, a median PFS of 4.4 months (95% CI, 2.5 to 5.4) and median OS of 7.3 months (95% CI, 5.6 to 14.6)
Research protocols typically use 20-80 mcg daily via subcutaneous injection, cycled 4 weeks on, 4 weeks off
This inhibition resulted in a two-fold increase in GJ expression in the liver compared to wild-type mice (Hsu et al
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