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Some individuals may experience mild digestive discomfort when starting supplementation, which typically resolves with continued use or dose adjustment
doi: 10.2337/diacare.28.12.2948 Summary Keywords type 2 diabetes, tirzepatide, counterregulatory response, hypoglycemia, clinical trial Citation Pieber TR, Svehlikova E, Urva S, Haupt A, Zhou C, Coskun T, Hller V, Fluhr G, Karanikas CA, Milicevic Z and Pratt EJ (2025) Counterregulatory response to hypoglycemia during a hypoglycemic clamp in people with type 2 diabetes treated with tirzepatide
Some people have higher receptor density in their gut, making them more sensitive to the GI effects of tirzepatide
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