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Background The relative effectiveness of sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for kidney protection, both individually and in combination, is incompletely understood
Gastrointestinal side effects are the most common and include: Nausea (reported in 12% to 29% of patients, depending on dose) Diarrhea (occurring in 13% to 23% of patients) Vomiting (affecting 4% to 9% of patients) Constipation (reported in 6% to 11% of patients) Abdominal pain and dyspepsia (affecting 6% to 9% of patients) Decreased appetite (common and often contributes to weight loss) These gastrointestinal symptoms typically occur during dose escalation and often improve with continued use
Fracture healing phases: Inflammatory phase (0-7 days) creates hematoma, recruits inflammatory cells, releases cytokines and growth factors initiating repair
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