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Originally approved by the FDA in 2017 to treat type 2 diabetes, semaglutide-based medications like Ozempic and Wegovy have now become the hottest off-label weight-loss solution
The reaction reflects regenerative signalling and barrier disruption during the adjustment period, not permanent harm
Clinicians should closely observe patients during treatment initiation and each titration step , documenting changes in weight, hydration status, gastrointestinal tolerance, and visual symptoms
Another systematic review found that people were able to maintain weight loss when they took a GLP-1 for two years or more
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