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Strong biological rationale, but no RCT with cancer endpoints
It was designed by Monash University researchers in the 1990s to keep the lipolytic and fat oxidation effects of full length growth hormone while removing the metabolic side effects on insulin resistance and glucose
NICE guidance (NG28 for type 2 diabetes, TA875 for semaglutide 2.4 mg, and TA664 for liraglutide 3 mg) recommends regular monitoring of patients on GLP-1 therapy, with particular attention to tolerability and adverse effects
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