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This formed the basis for Black's development of the first beta-blocker, propranolol, at Imperial Chemical Industries, a chemical conglomerate with pharmaceutical laboratories in Cheshire that he joined in 1958 and stayed with until 1964 when he moved to Smith Kline and French, an American pharmaceutical company with laboratories in Hertfordshire, South East England
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Mean (standard error [SE]) increases in 24-h HR from baseline were 3.3 (1.3) bpm for lixisenatide 20 g vs
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