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313 CP31398 administration can recover the transcriptional activity of partial mutant p53 and inhibit the thermal denaturation of wild-type p53 because of its Michael acceptor characteristics
In animal models and in the clinical setting, distinct pharmaceuticals have been described to modulate the function of transporters or enzymes involved in the metabolic dynamics of amino acids (Table 11)
When this mechanism does not work correctly, it can result in metabolic syndrome, nonalcoholic fatty liver disease, and type 2 diabetes
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