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Never cycling off: Constant stimulation can reduce receptor sensitivity
PLoS One 8 (2), e56306
Available clinical trial and pharmacovigilance data remain insufficient to establish whether semaglutide increases the risk of birth defects, miscarriage or other adverse outcomes, meaning treatment decisions should be made on a case-by-case basis with a licensed healthcare professional
Note that human-interest senolytic dosing is usually pulsed/intermittent (a few consecutive days per cycle), so this continuous schedule diverges from the typical senolytic paradigm
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