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The resulting -cell dysfunction manifests clinically as impaired glucose-stimulated insulin secretion (GSIS) and, ultimately, apoptosisa process confirmed in human autopsies showing ca

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This suggests that the total levels of the TCA cycle intermediates are also decreased, which was corroborated in the forebrain of mice during the chronic stage of the pilocarpine-SE model (Willis et al., 2010), but not in hippocampus (McDonald et al., 2017)