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Metformin reduces hepatic glucose production and improves insulin sensitivity, whilst Wegovy is a GLP-1 receptor agonist that suppresses appetite and promotes weight loss

Therefore, the therapeutic effect of GLP-1 analogs on MASH is attributed to body weight reduction through a decrease in appetite, followed by improvement in dyslipidemia and hepatic inflammation 33,34

This article covers the biological mechanisms at play, the timing and dosage considerations that matter, and the honest limitations of the current evidence base

Retatrutide is an unapproved investigational triple agonist (GLP-1, GIP, glucagon receptors) not licensed by the MHRA, EMA, or FDA for routine clinical use