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Common reasons include: Pernicious anemia , an autoimmune condition affecting intrinsic factor production Gastrointestinal disorders, such as Crohns disease or celiac disease Prolonged use of certain medications, like proton pump inhibitors Knowing these causes helps spot at-risk people

The result is a peptide with a half-life of 159 to 195 hours, roughly 7 to 8 days, making once-weekly administration possible

an early phase 1b study reported that co-administration was feasible and that each components pharmacokinetics were not meaningfully altered by the other, which motivated the phase 3 program [3]

TB-500 is related to a naturally occurring molecule called thymosin beta-4, found in many types of cells