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GLP-1RA corrects this imbalance through the following mechanisms: cell function protection and regeneration: GLP-1RA not only promotes insulin synthesis through cAMP-PKA pathway, but also realizes the increase of cell number and functional recovery by inhibiting cell apoptosis and promoting cell to cell transdifferentiation (for example, GCGR monoclonal antibody combined with GLP-1RA treatment can triple the number of cells in type 1 diabetes mice)
Al-SadawiMAAslamFMTaoMAlsaiqaliMAlmasryIOFanRet alEffects of GLP-1 agonists on mortality and arrhythmias in patients with type II diabetes
GH antagonizes insulin, drives lipolysis, and can raise hepatic glucose output
In fact, for most of us, making adjustments to increase GLP-1 naturallyeven if those changes are smallwill help us get to where we need to be
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