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Common Side Effects The most commonly reported side effects of semaglutide are [9]: Dyspepsia Dizziness GERD Nausea Diarrhea Abdominal pain Nasopharyngitis Injection-related complications (redness, pain, infection) Serious Side Effects These rare but considerably more serious side effects have also been reported [9]: Acute kidney injury Diabetic retinopathy complications in patients with type 2 diabetes Acute gallbladder disease Acute pancreatitis Safety Considerations Because some rodent studies showed a dose- and duration-dependent development of thyroid C-cell tumors and medullary thyroid carcinoma following semaglutide administration, subjects with a family history of these diseases or multiple endocrine neoplasia should be excluded from semaglutide trials [9]
GLP-1 Benefits at a Glance What Foods Increase GLP-1 Naturally
V., Lieberman, M., Sampalis, F
A more recent review describes this as a bidirectional relationship: GLP-1 drugs can shift the microbiome, and a person's existing microbiome may also predict how well they respond to the medication ( Frontiers in Endocrinology , 2026)
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