semaglutide and infertility FOGSI Obesity 2026 Update — Part 4/5 Ozempic, Wegovy and Mounjaro: What

A notable new side effect was dysesthesia (skin tingling or sensitivity), reported in about 21% of patients on the highest dose, though generally mild

It has skin soothing, antioxidant, and barrier protecting properties

This is particularly relevant for adults over 40, whose hormonal patterns, sleep architecture, and metabolic rhythms differ meaningfully from the younger populations in most clinical trial protocols

Potential Side Effects Linked to Receptor Activity The most common side effects in phase 2 trials were gastrointestinal, including nausea, vomiting, and diarrhoea, consistent with GLP-1R agonist class effects