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GLP-1RGIPR co-agonism is effective in the management of obesity and type 2 diabetes 1,2 , and lanifibranora nuclear-acting small-molecule triple agonist of PPAR, PPAR and PPARis in clinical phase 3 trials for the treatment of metabolic dysfunction-associated steatohepatitis 3

A novel and increasingly studied structure in this context is the primary cilium, a microtubule-based organelle that functions as a signaling hub for pathways including Sonic Hedgehog (Shh), Wnt/Wingless, and mechanistic target of rapamycin (mTOR)

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The picks ranked above do the same clinical work without the second line item