glp 1 incretin mimetics GLP-1 receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits The role of incretin mimetics

Both approaches require physician oversight, baseline lab work, and ongoing monitoring to improve doses and ensure safety

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Currently, there is an ongoing randomised double-masked placebo-controlled trial, the SUMMIT trial, studying the efficacy and safety of tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide and GLP-1 receptors, versus placebo in HFpEF patients with obesity (NCT04847557)