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Researchers explained the reduction in DIO3 expression by elevated levels of inhibitory histone in the DIO3 promoter area, indicating that overactive RA signaling can ectopically de-repress TH signaling ( RA also regulates the effects of THs on target tissues

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For context, tirzepatide 15 mg in the SURMOUNT trials had discontinuation rates around 6-7%

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The SURMOUNT-1 trial specifically noted that GI adverse events were the most common reason for treatment discontinuation at higher doses

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