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This study was important as there had been no previous reported data on the possible effects of hepatic impairment on the pharmacokinetics of SNAC, which is metabolized via -oxidation and glucuronidation and is highly bound to albumin

Conclusions The current study found that septic patients have higher levels of PyroGlu, lower levels of Glu, and lower erythrocyte GPX activity, suggesting that these biomarkers could be used as an indicator of glutathione depletion

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