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SA node effect shud be right from beginning, why sympathetic effect on SA shows after a lag at 24 weeks, also if it's as shown in graph peaks after hiatus is this due to drug induced Increased basal metabolic rate(obvioous will be increased HR)

For further information, refer to the New Zealand Formulary: Discuss potential adverse effects before initiating treatment Adverse effects of SGLT-2 inhibitors such as empagliflozin include: 11 Polyuria consider reducing diuretics before initiating treatment Genitourinary infections, e.g