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In kinetic isotope labeling experiments, an unlabelled carbon source like glucose or glutamine is replaced by a labeled one, and the labelling patterns of intermediates and products are measured at different time points (Wang et al., 2020)
doi: 10.1111/dom.14725 U.S
Therefore, the SGLT2-i induced elevated ANG II levels could act through AT2R resulting in vasodilation, sodium excretion, antiproliferative and anti-inflammation effects (51)
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