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The existing therapies targeting p53 all have some degree of limitations
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The same molecule appears under several designations, which is a practical problem for anyone reviewing the literature: A search on BPC-157 alone will miss part of the corpus, particularly the earlier inflammatory bowel work published under PL 14736
To determine the solution structural model of the p53 TAD2 -FOXO4-DRI complex using NMR spectroscopy, we recorded several sets of NMR experiments on two types of complexes: 13 C, 15 N-labelled p53 TAD2 -FOXO4-DRI and 13 C, 15 N-labelled FOXO4-LRI D -p53 TAD2 (see methods)
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