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Injectable therapy is easier to manage when refill planning happens before the last scheduled dose
Results maintenance requires ongoing or periodic use - stopping treatment leads to gradual regression over 2-6 months as new collagen formation stops and natural aging resumes
Ke et al., 2018
However, this conformational change reduces the space available to accommodate the -helix of the peptide increasing the steric hindrance between the bulky ionic lock (R17 Cagri- E14 Cagri ) and ECL2
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