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Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial

It rises early when liver cells become inflamed

Oxidative stress can promote 4-hydroxy-2-nonenal (4-HNE)-mediated modification of HSPA2, targeting it for degradation through the ubiquitin-proteasome system, which may lead to the loss of proteins required for meiosis and contribute to spermatogenic arrest ( Furthermore, multiple studies have demonstrated that heat stress-induced spermatogenic dysfunction 209 is closely associated with germ cell apoptosis, which displays both cell-type- and stage-specific 210 characteristics (Figure 1c) (Lue et al., 1999

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