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GCN2 phosphorylates eIF2, leading to ATF4 induction and upregulation of downstream targets including CHAC1
However, although TZDs can have cardiac benefits in selected patient cohorts 14 , the development of many Glitazars was terminated due to potential unfavourable effects on the cardiovascular and/or renal system 15
Mol Nutr Food Res 63(23):1801401 Neuman JC, Albright KA, Schalinske KL (2013) Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model
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