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Other benefits of ultra-long-acting GLP-1RAs include less fluctuation in blood concentration, improved gastrointestinal tolerance, and a simpler and more convenient once-a-week dosing regimen that improves the compliance of patients and the persistence of treatment (Gentilella et al., 2019)
273 Moreover, GLP-1RAs could decelerate the progression of OA and mitigate pathological damage in a rat OA model
So not to dwell on too much on that one
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