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The programme includes: REDEFINE 1 a 68-week efficacy and safety Phase III trial of once-weekly CagriSema, cagrilintide 2.4 mg and semaglutide 2.4 mg versus placebo in 3,417 adults with obesity or overweight with one or more comorbidities and without type 2 diabetes
38 WenX.QiuC.LiX.LinH.HuangY
It will: Validate the efficacy signals at larger scale, and at higher resolution Identify predictive markers of safety and tolerability Assess drug-specific differences in different applications Evaluate discontinuation and rebound risk Enable head-to-head drug comparisons as data matures This moves the program from proof-of-concept to clinically actionable stratification
Oxidation Reactions In the liver, the most important site of metabolism is the microsomal enzyme system
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