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The absence of clinical benefit in EVOKE is consistent with the interpretation that central pharmacodynamic effects are sub-therapeutic, and that the mechanistic pathways proposed on the basis of preclinical data may not be meaningfully engaged in vivo in humans

J Clin Endocrinol Metab 96:853860 Mabilleau G, Mieczkowska A, Irwin N, Flatt PR, Chappard D (2013) Optimal bone mechanical and material properties require a functional glucagon-like peptide-1 receptor

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