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The results indicated that LMP mutation carriers had a 3.03% lower overall weight loss compared to non-carriers, with no significant difference in short-term outcomes ( 6 months) but a significant reduction in long-term outcomes
Presented for research literature review only Saxena BB (1980)
Carnitine acetyltransferase (CrAT) can act as safety valve to catalyze the reversible transfer of acetyl groups between acetyl-CoA and acetylcarnitine, promoting the combination of excess acyl groups with carnitine, increasing the membrane permeability of these products and thus removing them from the mitochondria, allowing acylcarnitine to be formed in the mitochondrial matrix and exported to the plasma [7]
Despite these benefits, long-term LC administration has been associated to cardiovascular risks due its conversion to trimethylamine- N -oxide (TMAO) by the gut microbiota
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