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3 Degradation of GLP-1 and production of GLP-1RAs GLP-1 (7-36)NH 2 acts as the active form, and the N-terminal end of this peptide is readily recognized by dipeptidyl peptidase-4 (DPP-4), an exopeptidase released from vascular endothelium and other tissues that can be quickly cut between the 2nd and 3rd amino acids to produce GLP-1 (9-36)NH 2

This means identifying foods that satisfy you, meal timing that prevents excessive hunger, and exercise routines you actually enjoy

GLP-1based therapy is also mentioned in the 2026 ADA Standards of Care as part of risk-based treatment options for many adults with type 2 diabetes

Pharmacology & Therapeutics, 174, 17-26