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GLP-1s have this effect because they prevent muscles in the gut from contracting and also activate the vagus nerve, which is part of the nervous system that plays a role in gastrointestinal tract activity
Adding Retatrutide to this combination helps offset the significant appetite increase and water retention potential
Most plateaus resolve with diet review, dose optimization, or increased physical activity
doi: 10.1371/journal.pone.0157188 365 SeneviratneC
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