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doi: 10.3390/medicina57070669
Tirzepatide# Tirzepatide is a 39-amino acid peptide with a C20 fatty diacid side chain that activates two receptors: GIP receptor : Tirzepatide shows approximately 5-fold selectivity for GIP over GLP-1 receptors, representing a GIP-dominant dual agonist GLP-1 receptor : Provides complementary glucose-lowering and appetite-suppressing effects The GIP receptor engagement is a key differentiator from pure GLP-1 agonists like semaglutide
When the GLP-1 group was compared with patients taking SGLT2 inhibitors, the GLP-1 group showed a lower risk of acute pancreatitis recurrence (15.2%) compared with 24% in the SGLT2i group
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