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Yes B12 is watersoluble, and excess amounts are excreted naturally

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Notably, retinal screening appointments demonstrated significant attendance rates, with around 80% of patients participating compared to other screenings, highlighting this integrated screening strategys feasibility and potential success

Among the 25 studies included in the qualitative synthesis (16 in the meta-analysis), 15 focused specifically on serum cobalamin changes (reported by baseline and post-treatment means and standard deviations in pg/mL) and 10 reported homocysteine outcomes (means and standard deviations in mmol/L)