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Gu Y, Zhang Y, Shi X, et al
3.2 Epigenetic regulation Macrophage polarization is epigenetically regulated through DNA methylation, histone modifications, and non-coding RNAs, which collectively fine-tune gene expression and influence macrophage plasticity and disease roles ( Figure 2 )
Expert Review of Endocrinology & Metabolism, 2025) The Fertility Paradox Worth Discussing With Your Provider For patients not actively trying to conceive, restored ovulation can be an unexpected and clinically significant side effect of treatment meaning contraception planning should be part of the conversation when starting GLP-1 therapy for PCOS, not an afterthought
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