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H., Yoo, K
Dosing Strategy and Formulation Choices to Minimize Headache Occurrence Slower titration schedulesstarting at 2.5 mg weekly for 4 weeks before escalationreduce headache incidence compared to standard 5 mg initiation
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The maintenance comparison has not been directly studied, but indirect evidence suggests that patients who switch from tirzepatide to semaglutide for maintenance may experience partial regain due to the loss of the GIP receptor component (Frias et al., NEJM 2021)
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