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Key updates include the use of the American Heart Association PREVENT-ASCVD equations to guide primary-prevention lipid-lowering therapy decisions
The published volume limits are: Abdomen: 1.5 mL maximum per site Thigh: 1.0 mL maximum per site Upper arm: 0.5 mL maximum per site These limits come from a 2014 pharmacokinetic study (Usach et al., Journal of Controlled Release ) that measured solution retention after subcutaneous injection at increasing volumes
Yen FS, Hou MC, Liu JS, Hsu CC, Hwu CM
Participants had an average reduction in A1C of 2 to 2.3% depending on dosage
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