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In mouse studies, researchers reported improved health markers rather than obvious toxicity, but mouse safety does not predict human safety

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The consensus provides recommendations for the safe use of GLP-1 medications in type 1 management, including: Benefits of use in youth and adults Initiation and titration to reduce the risk of hypoglycemia (low blood sugar), hyperglycemia (high blood sugar), and DKA Screening and educational needs Diabetes technologies suggestions Monitoring and mitigating potential risks, including medication interactions and eye, gastrointestinal, muscle, and nutritional considerations Instructions for discontinuation during pregnancy and surgery Access and equity concerns In an effort to assist more clinicians and people with type 1 who are considering trying one of these off-label medications to personalize care and improve outcomes, diaTribe has created guides for the safe use of GLP-1-based treatments in type 1 diabetes to answer common questions and serve as a reference tool: The statement and 35 recommendations were endorsed by the American Association of Clinical Endocrinology, Association of Diabetes Care and Education Specialists, Breakthrough T1D, Advanced Technologies & Treatments for Diabetes, the International Society for Pediatric and Adolescent Diabetes, and the International Diabetes Federation Europe