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Long-term HFD consumption increased hepatic IKK- glutathionylation and NF-B suppression The mechanistic investigations in our cell culture studies provided evidence suggesting that intracellular GSSG accumulation sensitizes hepatocytes to TNF cytotoxicity via the induction of IKK- glutathionylation, leading to reduced IKK- phosphorylation and subsequent NF-B suppression
Likewise, LK-935, a pyridylethanol(phenylethyl)amine derivative, binds to the heme pocket of CYP51A1, similar to azoles, and suppresses sterol synthesis in hepatoma cells [21]
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