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Beyond glucose regulation, GLP-1 receptor agonists slow gastric emptying, which helps people feel fuller for longer periods and reduces appetite through effects on brain centers that control hunger
Peptides with short half-lives were often dismissed because efficacy could not be sustained, even when acute biological effects were robust
It is possible this could be in part due to the fact that these patients are receiving IV amiodarone for acute arrhythmias impending hemodynamic instability
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