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In a 3-month randomized controlled study of type 2 diabetes, it was found that the combination of liraglutide and sitagliptin had no effect on the composition of intestinal flora, had no effect on the alpha and beta diversity, but liraglutide resulted in an elevation of deoxycholic acid (DCA) levels, indicating potential modulation of bile acid metabolism (Smits et al., 2021)

Biomarkers and Genetic Factors Behind Incretin-Pathway Response Response to incretin-pathway compounds tracks with metabolic biomarkers such as fasting glucose, HbA1c, insulin resistance (HOMA-IR), lipids, and CRP

These reactions do not necessarily indicate a true allergy and often improve with continued use

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