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Abbreviations VPA: Valproic acid CNS: Central nervous system GABA: -Aminobutyric acid DNA: Deoxyribonucleic acid ROS: Reactive oxygen species MDA: Malondialdehyde GSH: Reduced glutathione SOD: Superoxide dismutase CAT: Catalase GPX: Glutathione peroxidase Nrf2: Nuclear factor E2-related factor 2 ARE: Antioxidant response elements TNF-: Tumor necrosis factor- IL-1: Interleukin-1 IFN-: Interferon gamma iNOS: Inducible nitric oxide synthase NF-B: Nuclear factor-kappa B COX-2: Cyclooxygenase-2 Bax: Bcl-2: Associated X protein ROS: Reactive oxygen species pNf-kB: Phosphonuclear factor kappa B Keap1: Kelch-like ECH-associated protein 1 NTDs: Neural tube defects ASD: Autism spectrum disorder HDAC: Histone deacetylase PARP: Poly (ADP-ribose) polymerase Bcl-2: B-cell lymphoma protein 2l ATP: Adenosine triphosphate mtDNA: Mitochondrial DNA MEK: Mitogen-activated protein kinase ERK: Extracellular regulated kinase MPT: Mitochondrial permeability transition LH: Luteinizing hormone FSH: Follicle stimulating hormone MDA: Malondialdehyde GST: Glutathione-S-transferase GPX: Glutathione peroxidase GR: Glutathione reductase MPP: Mitochondrial permeability transition pore ALT: Alanine amino transaminases AST: Aspartate amino transaminases ALP: Alkaline phosphatase LDH: Lactate dehydrogenase DTA: Diallyl trisulfide TJ-960: Shosaiko-to-go-keishikashakuyaku-to H 2 O 2 : Hydrogen peroxide HO-1: Heme oxygenase 1 References Ahmed A, El F, Mohamed H (2016) Apium Graveolens and Rosmarinus Officinalis protect from liver toxicity induced by sodium valproate in rats and potentiate its anticonvulsant activity on pentylenetetrazol-treated rats

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Expression of this mutated gene greatly reduces expression and operation of astrocytic glutamate transporters, thus leading to an excitotoxicity linked to psychosocial abnormalities and impaired cognition

Generally, a plant is extracted by one of two methods: one natural products method and traditional Chinese medicine method [94]