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Structurally, the quaternary nitrogen at position 1 carries a permanent positive charge that no change of pH removes

In keratinocytes, GHK-Cu has been shown to downregulate inflammatory cytokine production in response to challenge including IL-1, TNF-, and IL-6, the inflammatory mediators most associated with the chronic scalp inflammation seen in androgenetic alopecia.4 In fibroblasts, GHK-Cu stimulates collagen and elastin synthesis, supporting the structural matrix that follicles depend on for anchoring and nutrient supply