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Notably, although tetramers are generated at high protein concentrations, the truncation of either of the two key hydrophobic residues (Leu-344 and Leu-348) can shift the oligomerization state toward the formation of a stable dimer
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Stable gastric pentadecapeptide BPC 157 therapy
Finally, low glutamine in the core region of solid tumors led to histone hypermethylation due to decreased -ketoglutarate level, resulting in cell dedifferentiation and therapeutic resistance in melanoma cells [64]
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