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This nuclear presence of FOXO4 seems to be involved in maintaining the viability of senescent cells by possibly modulating downstream senescence-associated pathways, detailed by changes in p53, Ser15-phospho-p53, and p21 protein levels
Its also needed for fatty acid metabolism and amino acid metabolism , which are key for energy and healthy tissues
suggested a classification based on MRI with arthroscopy findings correlations 36 : Type I: thickening of articular cartilage and low signal changes, but no break Type II: articular cartilage breached
The blood-brain barrier and the hydration of the brain
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