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Bottom line Trulicity (dulaglutide) and Ozempic (semaglutide) are both weekly injections for treating type 2 diabetes

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Severe gastrointestinal adverse reactions may lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal impairment, requiring close monitoring of fluid status and kidney function

The principal target cell types for GLP-1 (islet cells stained with insulin antiserum) and GLP-2 (intestinal endocrine cells stained with GLP-2 receptor antiserum) are shown below the peptide sequences